These considerations are particularly key in the case of small cell lung cancer (SCLC), the most aggressive form of lung cancer (~15% of cases), where the sialic acid repressive “don’t touch me” glycocalyx can be decorated with heavy sialic-acid rich gangliosides and even poly-sialic acid (polymers of α2,8 linked sialic acids) decorating key SCLC surface molecules such as CD24 and CD56 (74, 75). This evidence concerns the gene CD24 and small cell lung carcinoma.