NCAM1 and small cell lung carcinoma: These considerations are particularly key in the case of small cell lung cancer (SCLC), the most aggressive form of lung cancer (~15% of cases), where the sialic acid repressive “don’t touch me” glycocalyx can be decorated with heavy sialic-acid rich gangliosides and even poly-sialic acid (polymers of α2,8 linked sialic acids) decorating key SCLC surface molecules such as CD24 and CD56 (74, 75).