- Suppression of CD8+ T cells (activation and proliferation) by distinct TME cytokines (stromal, myeloid, and tumor sources)- Inducers of tolerogenic behavior by Dendritic Cells or other APCs (e.g., macrophages) by relevant cytokines- MDSCs and Tregs are drivers of suppressive cytokines in the lung cancer TME. The gene discussed is CD8A; the disease is lung cancer.