The role of the antioxidant enzyme system in tumorigenesis, progression, and chemoresistance is garnering increasing attention, particularly the antioxidants superoxide dismutase (SOD) and peroxiredoxin 4 (PRX4), which are increasingly recognized for their strong association with the clinical characteristics and prognosis of CRC (2, 3). This evidence concerns the gene SOD1 and colorectal carcinoma.