The mitochondrial dynamics and mitophagy are also impaired during thedevelopment of Alzheimer’s disease(Fig. 2).This is evidenced by alterations in the expression of the ATG5, Beclin1, LC3A,LC3B, PINK1, TERT, BCL2, and BNIP3L genes detected in a mouse model of AD[51]. Here, BCL2 is linked to Alzheimer disease.