According to the analysis, [68Ga]Ga-NOTA-Mal-Cys-MZHer342 usage allowed researchers to detectHER2 overexpression in tumor tissue with a 91.7% specificity and to detectnegative HER2 expression with an 84.6% specificity, with a conversion ofHER2/neu status from positive to negative observed in seven patients. The gene discussed is ERBB2; the disease is neoplasm.