During the acute liver failure (ALF) phase, the time-dependent expression levels of UII and Ces1f mRNA exhibited opposite trends: UII mRNA began to increase 2 hours after LPS/D-GalN stimulation, peaked at 6 hours, remained elevated at 8 hours, and decreased to near-normal levels by 12 hours; conversely, Ces1f mRNA showed a significant decrease starting at 6 hours post-stimulation, reached its lowest point at 10 hours, and began to rise again by 12 hours. Here, UTS2 is linked to acute liver failure.