OTC and hepatocellular carcinoma: Our data show that the up-regulated proteins in 12-month-old livers from Casp2C320S and Casp2−/− mice are more positively associated with the daHep signature compared to age-matched Casp2+/+ mice and include proteins associated with dysregulated lipid metabolism and fatty acid oxidation that are predictive of HCC susceptibility (HADHA, DECR1, GDE1, HMGCS2, OTC, RNH1, TRMT1, FAM135A, and TXN1) (Fig. 8C and table S4A).