CASP2 and neoplasm: To define the early and age-related liver proteome changes that contribute to early hyperpolyploidy and enhanced liver damage in Casp2C320S mice, we analyzed and compared the global liver proteome from Casp2+/+, Casp2−/−, and Casp2C320S mice at 3, 12, and >18 months of age (before tumor observation).