This includes the up-regulation of several proteins in young caspase-2-deficient mice (HADHA, DECR1, GDE1, HMGCS2, OTC, RNH1, TRMT1, FAM135A, and TXN1), associated with dysregulated lipid metabolism and fatty acid oxidation, which may serve as early predictive markers of susceptibility to MASH and HCC. Here, OTC is linked to hepatocellular carcinoma.