For total tumor incidence, [Casp2+/+ versus Casp2−/−: χ2(1, N = 40) = 3.916, *P = 0.048] and [Casp2+/+ versus Casp2C320S: χ2(1, N = 44) = 13.333, ***P = 0.0003]. Here, CASP2 is linked to neoplasm.