We noted that the incidence of steatosis by 12 months of age is reduced in Casp2C320S mice [9%; X2 (1, N = 15) = 10.97, P < 0.001] and somewhat lower (albeit nonsignificant) in Casp2−/− (17.6%), when compared with steatosis incidence in age-matched Casp2+/+ mice (27%) (fig. This evidence concerns the gene CASP2 and steatosis.