TD139 treatment also increased the percentage of infiltrated Treg cells and transforming growth factor–β (TGF-β)–producing Treg cells among liver-infiltrating cells in an α-GalCer–induced hepatitis mouse model (22), suggesting that blockade of extracellular Galectin-3 promotes both Treg cell expansion and function. This evidence concerns the gene LGALS3 and hepatitis A virus infection.