Notably, Galectin-3 mRNA expression in peripheral CD14+ monocytes isolated from patients with T1D was significantly up-regulated compared to healthy controls (Fig. 1B), indicating that monocyte-derived Galectin-3 may contribute to the elevation of serum Galectin-3 in patients with T1D. This evidence concerns the gene LGALS3 and type 1 diabetes mellitus.