LGALS3 and Hyperglycemia: Galectin-3–deficient (Galectin-3−/−) mice exhibit remarkable resistance to streptozotocin (STZ)–induced hyperglycemia development, accompanied by notable down-regulation of interferon-γ (IFN-γ), tumor necrosis factor–α, interleukin-17 (IL-17), and inducible nitric oxide synthase in macrophages (15).