Future research should aim to identify the specific chemoattractant that is responsible for neutrophil recruitment in disease conditions—such as IL-8 (CXCL8) or other CXC chemokines, as well as damage-associated molecular patterns (DAMPs) (13, 14)—that orchestrate this delayed but significant neutrophil infiltration in canine AD. Here, CXCL8 is linked to Alzheimer disease.