Multiple clinical studies (29–31, 33–37) have been conducted to investigate the effects of intensive lipid-lowering therapies, including high-dose statins and PCSK9 inhibitors, on reducing the progression of atherosclerotic plaques among patients with coronary artery disease (at least one vessel with stenosis ≥20%; target segment with stenosis ≤50%) using IVUS imaging (Table 3). This evidence concerns the gene PCSK9 and coronary artery disorder.