Truncating PRF1 alleles are loss-of-function and align with neonatal-/early-infant-onset FHL2; notably, c.65delC has been reported among recurrent alleles in Chinese cohorts, and neonatal, sepsis-like courses have been described in FHL2 (Kim et al., 2014; Ma et al., 2020; Bi et al., 2021; Zhang et al., 2024). Here, PRF1 is linked to Sepsis.