This study successfully identified lipids (PC(18:2/18:2), PC(14:0/20:4) and PC(18:0/20:4)) and proteins (HP, RBP4, F13B and ITIH1) as robust biomarkers for the diagnosis and monitoring of cure in TB, through the integration of lipidomics, proteomics and MR analysis and demonstrate high‐accuracy multi‐omics diagnosis and cure monitoring models. Here, HP is linked to tuberculosis.