It is noteworthy that the multi‐omics diagnostic model (PC (18:2/18:2), PC (14:0/20:4), HP, RBP4) and cure‐monitoring model (PC (18:2/18:2), PC (18:0/20:4), HP, RBP4, F13B, and ITIH1) developed in this study show higher specificity and sensitivity compared to traditional biomarkers such as C‐reactive protein (sensitivity below 90% and specificity below 70%) for the diagnosis and therapeutic surveillance of TB [48, 49]. Here, ITIH1 is linked to tuberculosis.