CDIPT and Pythiosis: Representative sera from 3 pythiosis patients (who were infected with different P. insidiosum strains likely expressing the same proteins but with some amino acid variations) contained overlapping and distinct sets of antibodies against proteins from the P. insidiosum strain Pi-S (Fig. 1) and identified 55 immunoreactive protein spots, corresponding to 42 unique proteins (defined by LC-MS/MS; Table 1).