The patient’s laboratory work-up on hospital admission showed severe hypothyroidism with an fT4 of 6.8 pmol/L (SI: 0.53 ng/dL), TSH of 519.40 μIU/mL (SI: 519.40 mIU/L), and elevated TPO antibodies at 54.7 kU/L (SI: 54.7 IU/mL), confirming severe hypothyroidism. The gene discussed is TPO; the disease is hypothyroidism.