GRN and frontotemporal dementia: In cellular and animal models of progranulin-deficient frontotemporal lobar degeneration (FTLD-TDP), both canonical and non-canonical Wnt cascades are overactivated, implicating aberrant Wnt/β-catenin signalling in FTD pathology (de la Encarnación et al., 2016; Rodríguez-Periñán et al., 2023).