The mTOR signalling cascade (mTORC1/2) is implicated in neurodegenerative mechanisms across multiple disorders, including frontotemporal dementia (FTD) and PD, where it modulates autophagy, protein aggregation, and synaptic plasticity (Zhu et al., 2019; Querfurth and Lee, 2021). This evidence concerns the gene MTOR and Parkinson disease.