Radiological imaging of the brain (MRI, MRA, and MRV) revealed reversible, generalized atrophy, and his laboratory results confirmed macrophage activation syndrome (MAS) with a ferritin level of 26,195 μg/L, LDH: 1681 iu/L, D‐dimer: 33.34, fibrinogen: 1.49, triglycerides: 5.84, AST: 226 iu/L, ALT: 287 iu/L, ESR of 67 mml/h, CRP of 22 mg/L, HB of 8.1 g/dL, platelets of 127 × 10 ∗ 9/L, WBC of 7.5 × 10 ∗ 9/L, and ANC of 1.9 × 10 ∗ 9/L, and IL‐2 receptor concentration was over 20 ng/mL. This evidence concerns the gene CRP and macrophage activation syndrome.