ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, ACE: angiotensin-converting enzyme, ANCA: anti-neutrophil cytoplasmic antibody, ENA: extractable nuclear antigen, NMOSD: neuromyelitis optica spectrum disorders, MOGAD: myelin oligodendrocyte glycoprotein antibody-associated disease, SLE: systemic lupus erythematosus. The gene discussed is CRP; the disease is neuromyelitis optica.