In our study, low PlGF in IUGR pregnancies correlated with the most common placental abnormality, maternal vascular supply obstruction, highlighting impaired placental angiogenesis and perfusion and supporting the concept of “placental IUGR.” Consistent with our findings, Shinar et al. [19] reported that pregnancies with low PlGF were more likely to have an estimated fetal weight < 5th centile (73.8% vs 53%, p = 0.01). The gene discussed is PGF; the disease is fetal growth restriction.