5) CRAB criteria: Calcium elevation (C) - present (10.22 mg/dL); Renal dysfunction (R) - present (Cr 2.64); Anemia (A) - present (Hb 6.6); Bone disease (B) - present (pathologic fracture) The patient met diagnostic criteria for MM and demonstrated intermediate-risk cytogenetics based on FISH findings [10]. The gene discussed is GSTM1; the disease is Abnormal renal physiology.