NPM1 and chronic myelogenous leukemia, BCR-ABL1 positive: MPAL should not be diagnosed in the setting of chronic myeloid leukemia in blast crisis, AML with dysplastic changes, therapy-related AML, or when t(8;21), t(15;17), or inv (16) is present. By contrast, NPM1 or CEBPA mutations do not preclude the diagnosis of MPAL.