EPAS1 and obesity due to melanocortin 4 receptor deficiency: These investigators propose that the link between obesity and cardiomyopathy may be through changes in the microenvironment of adipose tissue (e.g., hypoxia) leading to HIF‐2α induction, which in turn triggers inflammation and cardiomyopathy, and that inflammation in adipose tissue is a significant cause of pathologic cardiac hypertrophy and heart failure, with HIF‐2α activation being a key mechanism in this process [31].