Acss2/HIF‐2α signaling was abnormally active in hypoxia and glucose deficiency and accelerated cell proliferation and colony formation in fibrosarcoma cells and colon cancer cells, migration and invasion in fibrosarcoma and colon cancer cells, and Acss2/HIF‐2α‐dependent cancer cells grown in mice showed faster tumor growth [69, 70]. The gene discussed is EPAS1; the disease is colonic neoplasm.