In acute respiratory distress syndrome (ARDS), HIF‐2α is induced through the induction of expression of vascular endothelial protein tyrosine phosphatase (VE‐PTP) and enhances the integrity of adherens junctions (AJs) between endothelial cells, thereby improving vascular endothelial barrier function and preventing edema formation and inflammatory cell infiltration [23]. This evidence concerns the gene PTPRB and acute respiratory distress syndrome.