The present study showed that the combination of AuNPs with specific anti‐IL17A Apt (M2) in an IMQ‐induced psoriasis mouse model boosted the anti‐inflammatory effect of anti‐IL17A Apt, especially in low dose, and alleviated the symptoms of psoriasis in the back skin of C57BL/6 mice. This evidence concerns the gene LYPLA2P1 and psoriasis.