For example, Belluardo et al. [23] studied NT‐BNP in an Italian outpatient cohort, while Macheret et al. [24] evaluated BNP levels in a community‐based sample from Olmsted County, Minnesota, both suggesting that BNP may be an unreliable signal in the early phases of hypertensive heart disease [25]. This evidence concerns the gene NPPB and hypertensive heart disease.