Leptin contributes to chronic inflammation and can suppress sodium/iodide symporter and Tg expression, potentially leading to morphological changes in the thyroid and disrupting hormone levels in individuals with obesity.1 Additionally, leptin plays a role in regulating the expression of the thyrotropin-releasing hormone gene.37,38 These findings align with our cohort results, which showed a reduction in LT4 dosage in the majority of patients, along with remission in 14.72% of patients by the end of the study. This evidence concerns the gene TRH and obesity due to melanocortin 4 receptor deficiency.