AIF1 and Alzheimer disease: Although we only found a significant increase of Iba-1 protein in Western blot analysis of TMG-treated WT and TgF344-AD rats (Figure 5B), we found a significant increase in the total number of microglia in TgF344-AD rats compared to WT (p < 0.001; Figure 8Ei) in both saline (p < 0.001) and TMG-treated groups (p < 0.001), with no interaction (p = 0.533).