B-cell depletion stops the B-cells regulatory effect on T-cells population (30); Preceding the release of TNF-alpha, IL-6 and IL-8, promoting angiogenesis, generating a pro-inflammatory environment, inducing keratinocyte proliferation, and attracting neutrophils (30); Increment the susceptibility to bacterial infection and modification of the microbiome (30). The gene discussed is TNF; the disease is bacterial infectious disease.