In fact, the infection with meningococci defective for HrpA/HrpB TPS is strongly impaired in the activation of caspase-1 and IL-1β and IL-18 release (Talà et al., 2022; Pagliuca et al., 2024), but if the integrity of the internalization vacuole is destabilized through DYNLT1-silencing (Driskell et al., 2007; Flores-Rodriguez et al., 2011; Yap and Winckler, 2022; Yap et al., 2022), caspase-1 activation occurs as in cells infected with wild-type meningococci (Talà et al., 2022). The gene discussed is CASP1; the disease is infection.