KEGG analysis displayed that the significant avenues of approach related to T2DM were PI3K‐Akt signaling pathway, FoxO signaling pathway, endocrine resistance, MAPK signaling pathway, mTOR signaling pathway, and AGE‐RAGE signaling pathway in diabetic complications (as shown in Figure 10(a)). This evidence concerns the gene PIK3CB and type 2 diabetes mellitus.