The PPI network was introduced into Cytoscape 3.9.0, and the 10 targets with the most significant representation of red nodes in the middle (SRC, PIK3R1, MAPK3, PIK3CA, MAPK1, EP300, TP53, STAT3, AKT1, and CTNNB1) played a central role in the occurrence and progress of T2DM. This evidence concerns the gene PIK3R1 and type 2 diabetes mellitus.