In this study, by constructing the PPI network of the JPXK recipe and T2DM intersection targets, we discovered that ESR1, JUN, SRC, PIK3R1, FOS, MAPK1, AKT1, TP53, RELA, and MAPK3 were the hub targets for the treatment of T2DM. Here, TP53 is linked to type 2 diabetes mellitus.