ESR1 and type 2 diabetes mellitus: The effective ingredients of the JPXK recipe in the treatment of T2DM were quercetin, luteolin, berberine, isorhamnetin, and kaempferol, and the essential targets were ESR1, JUN, SRC, PIK3R1, FOS, MAPK1, AKT1, TP53, RELA, and MAPK3.