The PPI network was introduced into Cytoscape 3.9.0, and the 10 targets with the most significant representation of red nodes in the middle (SRC, PIK3R1, MAPK3, PIK3CA, MAPK1, EP300, TP53, STAT3, AKT1, and CTNNB1) played a central role in the occurrence and progress of T2DM. The gene discussed is PIK3CA; the disease is type 2 diabetes mellitus.