Large ribosomal subunit protein uL24 is a large ribonucleoprotein complex responsible for intracellular protein synthesis; perilipin‐1 is involved in metabolic activities including severe familial partial lipodystrophy and early‐onset acute coronary syndrome; serpin B12 inhibits trypsin and plasmin but does not inhibit thrombin, coagulation factor Xa, or urokinase‐type plasminogen activator; additionally, collagen alpha‐2 (VI) chain, gastricsin, guanylate cyclase activator 2B, uroplakin‐2, tryptase beta‐2 (tryptase‐2), and putative transmembrane protein INAFM2 also showed significant changes. Here, SERPINB12 is linked to acute coronary syndrome.