Large ribosomal subunit protein uL24 is a large ribonucleoprotein complex responsible for intracellular protein synthesis; perilipin‐1 is involved in metabolic activities including severe familial partial lipodystrophy and early‐onset acute coronary syndrome; serpin B12 inhibits trypsin and plasmin but does not inhibit thrombin, coagulation factor Xa, or urokinase‐type plasminogen activator; additionally, collagen alpha‐2 (VI) chain, gastricsin, guanylate cyclase activator 2B, uroplakin‐2, tryptase beta‐2 (tryptase‐2), and putative transmembrane protein INAFM2 also showed significant changes. This evidence concerns the gene GUCA2B and familial partial lipodystrophy.