Preliminary screening with the chi-square or Fisher’s exact test showed that the CXCL10 rs4508917 and TREX1 rs11797 were significantly correlated with DLBCL susceptibility under the codominant and dominant models (p < 0.05), and IFNB1 rs1051922 was correlated with DLBCL susceptibility under the recessive model (p < 0.05). The gene discussed is TREX1; the disease is diffuse large B-cell lymphoma.