In glioblastoma, STAT3 phosphorylation was suppressed through SRGN knockdown (19); in contrast, STAT3 induced SRGN in nasopharyngeal carcinoma (69), suggesting a potential positive feedback loop in tumor cells that may also operate in TAMs, thereby sustaining a potent oncogenic signaling circuit. The gene discussed is SRGN; the disease is glioblastoma.