Immunohistochemical staining of cancer tissues and adjacent tissues in 8 patients with ccRCC consistently elicited elevated NME2 expression in tumor tissues (Figure 6), and Western blot analysis was performed on 3 pairs of ccRCC and adjacent normal tissues, a subset of the 8 pairs of samples mentioned in the “Data acquisition” section (Section 2.1). Here, NME2 is linked to nonpapillary renal cell carcinoma.