A schematic diagram is recommended here, depicting the stepwise process: (1) BsAb-mediated bridging of T cells and tumor cells, (2) immune synapse formation, (3) perforin/granzyme release, (4) cytokine secretion, (5) recruitment of NK cells and macrophages, and (6) co-stimulatory and checkpoint-modulating pathways. This evidence concerns the gene PRF1 and neoplasm.