Despite these discrepancies, additional data suggest that PPARγ contributes to mitochondrial health by stimulating biogenesis and restoring mitochondrial function, as demonstrated by the ability of PPARγ overexpression to reverse breast cancer-conditioned medium (BC-CM)-induced mitochondrial dysfunction (72) and by the effects of pioglitazone on mitochondrial biogenesis (73). Here, PPARG is linked to breast carcinoma.