PPARG and cancer: In adipocytes, certain oxime rexinoids and transcription factors act as agonists of the RXR: PPARγ heterodimer and are potent inducers of 3T3-L1 preadipocyte differentiation into mature adipocytes (124–126), implicating this axis in adipose tissue remodeling and potentially contributing to lipid depletion observed in cancer cachexia.