Six studies (n=4101) reported level 3 hypoglycemia, showing no significant difference between insulin efsitora and once daily basal insulins (RR 0.97, 95% CI: 0.42 to 2.24, p = 0.94) with no heterogeneity (I2 = 0%, p = 0.41) (Supplementary Figure S9). This evidence concerns the gene INS and Hypoglycemia.