Level 1 hypoglycemia data from six studies (n=4115) showed no statistically significant difference between insulin efsitora and once daily basal insulin groups (RR 1.04, 95% CI: 0.97 to 1.11, p = 0.24) with high heterogeneity (I2 = 65%, p = 0.01) (Supplementary Figure S7). This evidence concerns the gene INS and Hypoglycemia.