CD4 and Granuloma: Our SHAP-based feature importance analysis reveals that: CD4+ T cells are the central regulators of immune control in EPTB, playing well-established roles in IFN-γ-mediated protection, granuloma maintenance, and suppression of immune evasion; HB is a key modulator of immune responses and inflammation, where its dysregulation (either high or low) contributes to immune dysfunction, oxidative damage, and granuloma instability.