Transthyretin amyloidosis is a disease resulting from accumulation of misfolded proteins from a mutated or wildtype transthyretin (TTR) gene, into harmful amyloid fibril deposits, leading to polyneuropathy and/or cardiomyopathy Ruberg and Berk (2012). The gene discussed is TTR; the disease is Familial transthyretin-related amyloidosis.