In a rat periodontitis model, cashew gum polysaccharide (CG‐P)‐containing oral gel significantly reduced alveolar bone loss, decreased the mRNA expression of TNF‐α, IL‐1β, RANKL, and the RANKL/OPG ratio, and lowered myeloperoxidase activity in gingival tissues [38]. This evidence concerns the gene IL1B and periodontitis.