Morinda officinalis polysaccharide not only reduces the level of fibronectin extra domain A, an endogenous TLR4 ligand in the periodontal inflammatory milieu but also suppresses the activation of NLRP3 inflammasome, leading to decreased IL‐1β and IL‐18 production and reduced inflammatory cell infiltration in periodontitis rats [42, 51, 52]. This evidence concerns the gene TLR4 and periodontitis.