In a rat periodontitis model, cashew gum polysaccharide (CG‐P)‐containing oral gel significantly reduced alveolar bone loss, decreased the mRNA expression of TNF‐α, IL‐1β, RANKL, and the RANKL/OPG ratio, and lowered myeloperoxidase activity in gingival tissues [38]. The gene discussed is TNFSF11; the disease is periodontitis.