IGHE and Netherton syndrome: Netherton syndrome (NS), first described by Comèl in 1949 and later named by Netherton in 1958, is a rare autosomal recessive genodermatosis clinically characterized by ichthyosis linearis circumflexa (ILC), atopic features (a predisposition to atopic manifestations including eczema, allergies, and elevated serum IgE levels), and abnormalities in hair shaft structure known as trichorrhexis invaginata (TI) (also termed “bamboo hair”) [1].