Epithelial-mesenchymal transition (EMT) -a dynamic and reversible biological program is pivotal process in the metastasis of HCC, marked by the loss of epithelial markers such as E-cadherin and cytokeratins, and the acquisition of mesenchymal markers like N-cadherin and vimentin, which facilitate tumour cell invasion and dissemination [99,100,[144], [145], [146]]. This evidence concerns the gene CDH2 and hepatocellular carcinoma.