They secrete pro-angiogenic factors, as VEGF, EGF, PDGF, TGF-β, that initiate neovascularization, as well as matrix metalloproteinases, such as MMP-2, MMP-9, which remodel extracellular matrix in favor of tumour cell invasion [[185], [186], [187]]. This evidence concerns the gene EGF and neoplasm.