Moreover, TAMs accomplish this by promoting immune evasion: generating regulatory T cell infiltration via the production of IL-10 and TGF-β, as well as chemokines [191]; while also expressing immune checkpoint molecules such as PD-1 that interact with PD-L1 ligand on tumour cells impeding the function of CD8+ T cells [192,193]. The gene discussed is CD8A; the disease is neoplasm.