Triggered by 808 nm laser illumination,robust ROSs were generated through the photodynamic effect of ETTCnanoparticles, which further cleaved the Se–Se linkages, releasingthe TRPM2 plasmid for improving TRPM2 expression in cancer cells.Simultaneously, ROSs also activated TRPM2 to induce Ca2+ influx, which inhibited early autophagy and up-regulated intracellularROS production, ultimately leading to the death of TRPM2-overexpressingcancer cells both in vitro and in vivo. This evidence concerns the gene TRPM2 and cancer.