TRPM2 and cancer: Recently, they developed CM nanoparticles with the capability ofNIR-triggered in situ release of nitric oxide (NO),realizing the activation of TRPV1 for eliminating glioblastoma. These works provide CM-based photodynamic systemsfor activating TRPM2 and TRPV1, paving the way to establish new platformsusing ROS-sensitive Ca2+ channels as promising targetsand/or tools for cancer therapy.