On the other hand, CMs exhibited robustexternal-light-reliable or -free photodynamic and NIR-I/II activephotothermal effects, which mediates the oxidative stress- and/orheat-induced activation of Ca2+ channels including TRPV1,TRPA1, and TRPM2, thus allowing for the on-demand modulating biologicalfunctions, including cancer and thrombolysis therapy, remote neurostimulation,and glycemic management. Here, TRPV1 is linked to cancer.