Professor Ingrid E. Scheffer led with 34 publications and 2,490 citations, reflecting her pivotal role in bridging clinical and genetic research—including contributions to DEE classification and the identification of SCN1A variants in Dravet syndrome, a prototypical DEE (15). The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.