In C9orf72‐related ALS/FTD models, NLRP3 inflammasome activation and subsequent IL‐1β production significantly enhanced ADAM10‐mediated TREM2 cleavage, elevating sTREM2 levels [67]; this cleavage potentially disrupted TREM2 immunomodulatory functions. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.