Univariate logistic regression analysis identified several risk factors for HBoV‐positive severe pneumonia, including airway or bronchopulmonary dysplasia, presence of fever, shortness of breath, nasal flaring, inspiratory retractions, wheezing, cardiovascular and hematological complications, and decreased Hb, ALB, lymphocytes (L), and elevated neutrophils (N), CRP, and PCT levels. The gene discussed is GSTM1; the disease is bronchopulmonary dysplasia.