However, the biological effects of SUCNR1 may be tissue‐specific, such as, in the renal interstitial fibrosis model, where the receptor exacerbates pathological injury by activating profibrotic M2‐type macrophages [44], and in the lung cancer microenvironment, where SUCNR1‐mediated M2 polarization of tumor‐associated macrophages promotes malignant metastasis [42]. The gene discussed is SUCNR1; the disease is lung carcinoma.