Moreover, the colocalization of F4/80+/CD206+ cells in the gut of NEC mice was higher than that in the control group (p < 0.05), but the coexpression of these cells was suppressed by succinate supplementation in the NEC group (p < 0.05), while treatment with the PI3K inhibitor LY294002 partially restored the expression (p < 0.05 and Figure 8j,k). This evidence concerns the gene MRC1 and necrotizing enterocolitis.