HCCS was found to be significantly upregulated in multiple cancer types, including breast invasive carcinoma (BRCA), kidney chromophobe (KICH), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), and uterine corpus endometrial carcinoma (UCEC) (Figure 1a). Here, HCCS is linked to squamous cell lung carcinoma.