Briefly, the release of perfringolysin O (pfo, from Clostridium perfringens) [49] induced by non‐invasive NIR under acidic tumor conditions initiates a perforating effect on tumor cells, enhancing the spread of tumor antigen release and thereby activating a variety of innate immune signaling pathways, including the TLRs, cGAS‐STING, and NLRs pathways. This evidence concerns the gene CGAS and neoplasm.