Compound 19 → ↑ GRP78 → ↑ ATF-4 and XBP-1 → ↑ CHOP → ↑ IRE1 → ↑ JNK → ↑ c-Jun → ↑ p53 → ↑ Caspase-3 and Caspase-9 → Apoptosis → ↓ Tumor Growth. Here, MAPK8 is linked to neoplasm.