PROS1 and neoplasm: In Vitro: PEITC+Gefitinib inhibited cell growth and induced apoptosis, decreasing the antiapoptotic protein Mcl-1 via a proteasomal degradation mechanism involving the ER stress pathway. In Vivo: The PEITC-Gefitinib combination significantly inhibited NCI-H1299 xenograft tumor growth, without causing significant toxicity