Similarly, a combination of Phenethyl Isothiocyanate and Gefitinib enhances ER stress-induced apoptosis by upregulating PERK-eIF2α-CHOP signaling, increasing pro-apoptotic Noxa and downregulating the survival protein Mcl-1, thereby amplifying cancer cell death (Zhang Q. et al., 2020). The gene discussed is DDIT3; the disease is cancer.