Compound 19 → ↑ GRP78 → ↑ ATF-4 and XBP-1 → ↑ CHOP → ↑ IRE1 → ↑ JNK → ↑ c-Jun → ↑ p53 → ↑ Caspase-3 and Caspase-9 → Apoptosis → ↓ Tumor Growth. The gene discussed is DDIT3; the disease is neoplasm.