SREBF1 and esophageal squamous cell carcinoma: All together, these studies suggest that SREBP1 is a central factor transcriptionally regulating ESCC cancer progression, SREBP1 overexpression promotes ESCC progression by enhancing fatty acid biosynthesis, while its silencing suppresses tumor cell proliferation, migration, and invasion, highlighting SREBP1 as key therapeutic target (Wang J. et al., 2020).