The aim of this study is to evaluate imaging features on conventional MRI for MGMT promoter methylation such as tumor characteristics; tumor volume, tumor necrosis volume, and edema volume by using two different DL models, DeepBraTumIA (DeepBraTumIA, 2025) and Raidionics (Bouget et al., 2023; GitHub, 2023), to assess the DL-models ability to prediction of MGMT methylation using raw segmentation outputs. The gene discussed is MGMT; the disease is neoplasm.