While this limits tumor detectability,it simultaneously reinforces the probe’s target specificity.Similar target-dependent imaging patterns have been reported for other 68Ga-labeled tracers, in which tracer accumulation closelycorrelates with target expression levels across different tumor types. These findings indicate that TfR1-targeted PETprimarily delineates molecular target distribution rather than servingas a general-purpose tumor detection modality. The gene discussed is TFRC; the disease is neoplasm.